Notice (8): file_put_contents(): Write of 268 bytes failed with errno=28 No space left on device [CORE/src/Log/Engine/FileLog.php, line 140]

        if (!$mask) {
            file_put_contents($pathname, $message . "\n", FILE_APPEND);

file_put_contents - [internal], line ??
Cake\Log\Engine\FileLog::log() - CORE/src/Log/Engine/FileLog.php, line 140
Cake\Log\Log::write() - CORE/src/Log/Log.php, line 392
Cake\Log\Log::warning() - CORE/src/Log/Log.php, line 477
DebugKit\ToolbarService::isSuspiciouslyProduction() - ROOT/vendor/cakephp/debug_kit/src/ToolbarService.php, line 169
DebugKit\ToolbarService::isEnabled() - ROOT/vendor/cakephp/debug_kit/src/ToolbarService.php, line 105
DebugKit\Plugin::bootstrap() - ROOT/vendor/cakephp/debug_kit/src/Plugin.php, line 48
Cake\Http\BaseApplication::pluginBootstrap() - CORE/src/Http/BaseApplication.php, line 182
Cake\Http\Server::bootstrap() - CORE/src/Http/Server.php, line 111
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 79
[main] - ROOT/webroot/index.php, line 40

Notice (8): SplFileObject::fwrite() [<a href='https://secure.php.net/splfileobject.fwrite'>splfileobject.fwrite</a>]: Write of 5437 bytes failed with errno=28 No space left on device [CORE/src/Cache/Engine/FileEngine.php, line 141]

Code Context

        $success = $this->_File->ftruncate(0) &&
            $this->_File->fwrite($contents) &&
            $this->_File->fflush();

SplFileObject::fwrite() - [internal], line ??
Cake\Cache\Engine\FileEngine::set() - CORE/src/Cache/Engine/FileEngine.php, line 141
Cake\Database\Schema\CachedCollection::describe() - CORE/src/Database/Schema/CachedCollection.php, line 85
Cake\ORM\Table::getSchema() - CORE/src/ORM/Table.php, line 513
Cake\ORM\Query::addDefaultTypes() - CORE/src/ORM/Query.php, line 290
Cake\ORM\Query::__construct() - CORE/src/ORM/Query.php, line 184
Cake\ORM\Table::query() - CORE/src/ORM/Table.php, line 1702
Cake\ORM\Table::find() - CORE/src/ORM/Table.php, line 1263
App\Controller\NewsController::action_() - APP/Controller/NewsController.php, line 6426
App\Controller\NewsController::get_data() - APP/Controller/NewsController.php, line 5701
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5625
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3436
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317

Notice (8): unserialize() [<a href='https://secure.php.net/function.unserialize'>function.unserialize</a>]: Error at offset 16363 of 16373 bytes [APP/Controller/NewsController.php, line 5571]

Code Context

               {
                      $a=unserialize($line2);
               }

unserialize - [internal], line ??
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5571
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::action_() - APP/Controller/NewsController.php, line 6481
App\Controller\NewsController::get_data() - APP/Controller/NewsController.php, line 5701
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5625
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3436
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73

Warning (2): Undefined array key "nsort" [APP/Controller/NewsController.php, line 3613]

Code Context

                
                $nav_url.="<a href='".$website_info[0]["nsort"]["nsort_url"]."'>".$website_info[0]["nsort"]["nsort_name"]."</a>";

App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3613
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\AssetMiddleware::process() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 77
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Error\Middleware\ErrorHandlerMiddleware::process() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 126

Warning (2): Trying to access array offset on value of type null [APP/Controller/NewsController.php, line 3613]

Code Context

                
                $nav_url.="<a href='".$website_info[0]["nsort"]["nsort_url"]."'>".$website_info[0]["nsort"]["nsort_name"]."</a>";

App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3613
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\AssetMiddleware::process() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 77
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Error\Middleware\ErrorHandlerMiddleware::process() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 126

Warning (2): Undefined array key "nsort" [APP/Controller/NewsController.php, line 3613]

Code Context

                
                $nav_url.="<a href='".$website_info[0]["nsort"]["nsort_url"]."'>".$website_info[0]["nsort"]["nsort_name"]."</a>";

App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3613
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\AssetMiddleware::process() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 77
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Error\Middleware\ErrorHandlerMiddleware::process() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 126

Warning (2): Trying to access array offset on value of type null [APP/Controller/NewsController.php, line 3613]

Code Context

                
                $nav_url.="<a href='".$website_info[0]["nsort"]["nsort_url"]."'>".$website_info[0]["nsort"]["nsort_name"]."</a>";

App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3613
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\AssetMiddleware::process() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 77
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Error\Middleware\ErrorHandlerMiddleware::process() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 126

Notice (8): unserialize() [<a href='https://secure.php.net/function.unserialize'>function.unserialize</a>]: Error at offset 16147 of 16373 bytes [APP/Controller/NewsController.php, line 5571]

Code Context

               {
                      $a=unserialize($line2);
               }

unserialize - [internal], line ??
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5571
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3698
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73

中国科学家为15种肿瘤的细胞“画像”

Warning (2): Undefined array key "nsort" [ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430]

Code Context

          <div class="info"> 
            <span><a href="<?php echo $website_info[0]["nsort"]["nsort_url"];?>"><i class="fa fa-columns"></i><?php echo $website_info[0]["nsort"]["nsort_name"];?></a></span> 
            <span><i class="fa fa-clock-o"></i><?php echo $website_info[0]["submission_date"];?></span>

include - ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430
Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1184
Cake\View\View::_render() - CORE/src/View/View.php, line 1138
Cake\View\View::render() - CORE/src/View/View.php, line 769
Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 762
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3938
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73

Notice: file_put_contents() [function.file-put-contents]: Write of 2421 bytes failed with errno=28 No space left on device in /www/wwwroot/www.adminso.com/vendor/cakephp/cakephp/src/Log/Engine/FileLog.php on line 140

Warning (2): Trying to access array offset on value of type null [ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430]Code Context          <div class="info"> 
            <span><a href="<?php echo $website_info[0]["nsort"]["nsort_url"];?>"><i class="fa fa-columns"></i><?php echo $website_info[0]["nsort"]["nsort_name"];?></a></span> 
            <span><i class="fa fa-clock-o"></i><?php echo $website_info[0]["submission_date"];?></span> 
include - ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430
Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1184
Cake\View\View::_render() - CORE/src/View/View.php, line 1138
Cake\View\View::render() - CORE/src/View/View.php, line 769
Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 762
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3938
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73

Notice: file_put_contents() [function.file-put-contents]: Write of 2445 bytes failed with errno=28 No space left on device in /www/wwwroot/www.adminso.com/vendor/cakephp/cakephp/src/Log/Engine/FileLog.php on line 140
">

Warning (2): Undefined array key "nsort" [ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430]Code Context          <div class="info"> 
            <span><a href="<?php echo $website_info[0]["nsort"]["nsort_url"];?>"><i class="fa fa-columns"></i><?php echo $website_info[0]["nsort"]["nsort_name"];?></a></span> 
            <span><i class="fa fa-clock-o"></i><?php echo $website_info[0]["submission_date"];?></span> 
include - ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430
Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1184
Cake\View\View::_render() - CORE/src/View/View.php, line 1138
Cake\View\View::render() - CORE/src/View/View.php, line 769
Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 762
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3938
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73

Warning (2): Trying to access array offset on value of type null [ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430]Code Context          <div class="info"> 
            <span><a href="<?php echo $website_info[0]["nsort"]["nsort_url"];?>"><i class="fa fa-columns"></i><?php echo $website_info[0]["nsort"]["nsort_name"];?></a></span> 
            <span><i class="fa fa-clock-o"></i><?php echo $website_info[0]["submission_date"];?></span> 
include - ROOT/plugins/Kuhuang/templates/Websites/view.php, line 430
Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1184
Cake\View\View::_render() - CORE/src/View/View.php, line 1138
Cake\View\View::render() - CORE/src/View/View.php, line 769
Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 762
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3938
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73

新华社北京2月7日电（记者林苗苗、侠克）癌种不同，肿瘤的细胞组成也存在差别，从而导致肿瘤的发生发展具有不同特点。近日，中国科学家从单细胞水平对胃癌、结直肠癌、肝癌、肺癌、乳腺癌等15种癌症的肿瘤浸润髓系细胞特征进行了系统性刻画

新华社北京2月7日电（记者林苗苗、侠克）癌种不同，肿瘤的细胞组成也存在差别，从而导致肿瘤的发生发展具有不同特点。近日，中国科学家从单细胞水平对胃癌、结直肠癌、肝癌、肺癌、乳腺癌等15种癌症的肿瘤浸润髓系细胞特征进行了系统性刻画。

这项由北京大学肿瘤医院季加孚团队和北京大学生物医学前沿创新中心张泽民课题组合作的研究论文，近日发表在国际学术期刊《细胞》上。

研究团队比较了肥大细胞、树突状细胞以及肿瘤相关巨噬细胞等髓系细胞类群在不同癌种内的特性，为靶向不同癌种内髓系细胞的免疫治疗提供了重要依据。

据介绍，肿瘤具有复杂的生态系统，癌细胞通过与多种其他类型的细胞相互作用形成复杂的细胞调控网络。其中，髓系细胞在调节肿瘤炎症反应以及血管生成等方面发挥着重要作用，因而成为继淋巴细胞之后癌症治疗临床研究的又一热门靶细胞。

我国是胃癌高发国家。科学家在研究中发现，对比癌旁的正常组织，胃癌肿瘤组织中的肥大细胞比例更高，表明肿瘤组织中的肥大细胞累积在胃癌的发生和进展过程中起着重要作用。胃癌肿瘤组织中存在着上调促血管生成相关信号通路的巨噬细胞类群，表明巨噬细胞类群在胃癌肿瘤微环境中起着重要作用。

研究团队通过进一步整合团队产出的单细胞转录组测序数据及已发表的公共数据，构建了包括胃癌在内的15个癌种的髓系细胞图谱，并系统比较各髓系细胞类群在不同的癌种间组成、发育及功能上的异同。

研究发现，肥大细胞在多癌种内呈现不同的功能状态，不同类型癌症中均存在着上调促血管生成相关信号通路的巨噬细胞类群。巨噬细胞在不同癌种内呈现高度异质性，意味着在进行针对巨噬细胞的免疫治疗方案时，尤其需要考虑其在不同癌种内的转录特异性。

标签: 中国科学家 15种肿瘤细胞画像

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